What are the advantages of PHENIBUT

Phenibut: A powerful anxiolytic

0

Phenibut is actually not a nootropic at all; the body gets used to the effects and slowly builds a tolerance to it. In addition, it can produce a slight physical dependence, which speaks against the nootropic definitions established by Giurgea & Skondia.

As long as it is used responsibly, the above side effects should not occur, and it can also help the user overcome negative mental states and increase sociability in social situations.

More ...

In my opinion, the benefits outweigh this. Those who do not overdose or chronically use Phenibut are on the safe side. By and large, it is a safe substance (has a long research history) that is also used as a drug (Eastern Europe).

Phenibut is a GABA derivative that is used as an anxiolytic in therapies for anxiety and restlessness.

Russian researchers first made it in the 1960s (along with Picamilon); in Russia it is still sold today as a psychotropic drug and is used in the treatment of stress, anxiety and sleep disorders.

In western countries it is mainly sold as a dietary supplement.

The attached phenyl ring allows GABA (gamma-amino-butyric acid) to cross the blood-brain barrier and enter the brain.

The name Phenibut is made up of the phenyl molecule and GABA (β-phenyl-γ-aminobutyric acid).

GABA is a natural substance that is mainly found in the CNS. It is one of the most important neurotransmitters (messenger substances), which is known for its anti-anxiety and stress-relieving, relaxing and sleep-promoting properties.

Phenibut is also said to have neuroprotective properties and increases in memory performance.

Other names: Phenybut, Fenibut, PhGABA, (RS)-4-amino-3-phenylbutanoic acid, beta-phenyl-gamma-aminobutyric acid

Mood

sleep

Quiet

Available here:

  • Phenibut is a form of GABA that allows GABA to be better absorbed by the body.
  • It reduces anxiety and restlessness, improves sleep, increases the ability to think, reduces stress levels, and increases social skills in dealing with other people.
  • It appears to provide better recovery between training days in exercise, and there is evidence that it increases the levels of growth hormone in the body.
  • Dosage: 250-1500mg per day. As a rule, however, 500mg is sufficient. It is mainly sold as a supplement in powder (bitter taste) or capsule form - I recommend the latter dosage form.
  • It should not be taken with alcohol or other GABA-active substances.
  • The effect only becomes apparent after a few hours. It unfolds in an increased mood, euphoria, talkativeness, and ensures a balanced feeling (anxiolytic). It can last all day (up to 32 hours).
  • Some users use it as an aid in lucid dreaming (lucid dreaming).
  • Over time, tolerance develops and the effect weakens, and addiction can also develop. For these reasons, it should only be taken sporadically, or in a ratio of 1: 1 (on: off days)
  • Overdosing can cause side effects such as nausea, tiredness, haunted dreams (good & bad), numb limbs, and drowsiness.

history

A brief overview of the history of Phenibut:

Not just for cosmonauts 🙂

  • 1963 - In St. Petersburg, a team under the supervision of the Russian researcher Prof. Perekalin synthesizes for the first time a substance called β-phenyl-γ-aminobutyric acid - an experimental drug that is to be used to treat children with mental illnesses.
  • 1964 - Professor Khaunma names the substance Phenigamma and reports for the first time about its calming effect in the Byulleten Eksperimental’noi Biologii i Meditsiny. (1)
  • 1975 - Phenigamma is also available to the public under the name Phenibut. The Soviet government recommends it for astronauts on space flights because of its mentally calming and stimulating effect.
  • 2001 - Phenibut's nootropic properties have been mentioned in over 3000 research papers.
  • 2013 and later - It is offered worldwide as a dietary supplement, nootropic, sleep aid, or muscle relaxant (fitness).

dosage

Phenibut should never be taken with alcohol or drugs that affect the GABA concentration (e.g. benzodiazepines, GHB, GBL, Picamilon), as otherwise the Gaba receptors are overexcited, which can lead to respiratory depression, memory loss or loss of consciousness.

  • The recommended daily dose is between 250mg and 1500g (oral consumption). Beginners choose a low dose to see how the body reacts. The amount can be increased as required, but should not exceed 3g, otherwise you risk an overdose.

The dose can vary depending on the route of application. Nasal: 200mg (but burns heavily), Sublingual: 125mg (attacks tooth enamel). However, only oral intake is really recommended; a daily amount of 500mg is sufficient for most people.

  • The body gets used to phenibut over time and develops a tolerance to it (= effect weakens), on top of that, physical dependence can develop after 10 days of continuous consumption. (4) (5) (6)

From this point of view, it should only be used sporadically (max. 2 - 3 times per week) or in cycles (ratio 1: 1, for example: take for 1 week, discontinue for 1 week).

Most of the research was done with maximum doses of up to 3g / day, at which no psychological side effects were noticeable. (2) (3)

Dosage forms:

Phenibut is usually available in powder or capsule form. The usual portioning is 250mg or 500mg per pill.

Properties:

The powder tastes very bitter & sour; Since it is water-soluble, it is recommended to consume it with a drink (e.g. juice).

Half-life and onset of effects:

The half-life for a dose of 250 mg is about 5 hours (2). Phenibut is active in the blood for several hours (sometimes over 24 hours). The effect usually only occurs after a few hours (sometimes only after 3 - 6 hours) and can subtly last the whole day.

Effect & mode of action

GABA

Gamma-amino-butyric acid is a neurotransmitter (messenger substance) that is responsible for regulating neuronal excitability in the central nervous system (CNS). Essentially, it keeps the brain from becoming hyperactive.

Comparison of the molecular structures of related substances Bild @ smart-drugs.com

GABA occurs naturally in the brain, which is why it normally does not have to cross the blood-brain barrier to be effective.

Phenibut is a modification of GABA that allows GABA to cross the blood-brain barrier more effectively.

Dopamine

Phenibut increases the levels of dopamine in the brain. Dopamine is an important messenger substance, which is also called the happiness hormone. It plays a role in increasing motivation and drive. (7)

Mood-lifting

It has anti-depressant properties, which reduce irritability and minimize fatigue. It also has a positive influence on the mood. (2)

Sports

Phenibut could also be of interest to bodybuilders and strength athletes.

Also interesting for strength athletes

It seems to promote the release of growth hormones (after exercise).

  • In a study that was carried out with strength athletes, an increase in growth hormone concentrations of 375% during the rest phase and 175% after training was observed when GABA was supplemented. In addition, the substance baclofen (which has the same mechanism of action as phenibut) seems to increase growth hormone synthesis. (8) (9) (10) (11)
  • It's anti-hypoxic. When a muscle is used for a long time it receives less oxygen and becomes hypoxic. This metabolic effect leads to hypertrophy and could lower tolerance to metabolic stress, allowing the user to exercise harder. (2)
  • Phenibut is neuroprotective and expands the energy potential of the cells, which consequently could increase the exercise capacity. (2)

Phenibut should not be classified as a performance enhancer, as excessive consumption decreases performance. It is more of a "recovery enhancer" that improves the recovery time between workouts.

sleep

It inhibits the neurons in the brain thereby reducing the time it takes to fall asleep, improving the quality of sleep, and promoting deep sleep. Some users report that they wake up more refreshed and rested after consuming phenibut.

travel sickness

It seems to have an interesting effect on motion sickness. In experiments with rabbits, changes in the blood flow in the brain were observed, which had a positive effect on the animals' sense of balance. (12)

Brain region

Phenibut improves communication between the hemispheres of the brain.

Side effects & safety

Attention!

If used incorrectly (e.g. overdosing), side effects such as nausea, diarrhea, tiredness, memory disorders and balance disorders occur.

There are hardly any reports of allergic reactions.

Phenibut can cause addiction and withdrawal symptoms after a short time. (13) (14)

In higher doses, it can damage the liver. (7)

There is evidence that drug interactions with epilepsy drugs are possible. (15)

legality

Phenibut does not appear in the Narcotics Act (BTMG) and does not appear to be listed as a medicinal product, but it cannot be clearly stated whether it falls under the Medicines Act (AMG).

It is sold as a sports supplement in many western countries.

Buy Phenibut

Phenibut is not available in German online shops, which is probably due to the unclear legal situation in this country.

If you want to order Phenibut, you have to import it from foreign traders. It is e.g. available from our partner shops (click the link to be forwarded to the shop):

It is also offered by some retailers on Ebay:

1. http://www.springer.com/biomed/journal/10517

2. Phenibut (beta-phenyl-GABA): a tranquilizer and nootropic drug. Lapin I. CNS Drug Rev. 2001 Winter; 7 (4): 471-81.

3. Sytinsky, I.A., soldierskov, A.T., 1978. Neurochemical basis of the therapeutic effect of gamma-aminobutyric acid and its derivatives. Prog. Neurobiol. 10,
89–133.

4. Effect of multiple daily administration of fenibut and diazepam on GABA and benzodiazepine receptors in the mouse brain. Riago LK, Sarv KhA, Allikmets LKh. Biull Eksp Biol Med. 1983 Dec; 96 (12): 49-50.

5. Peripheral mechanism of the phenomenon of fenibut habituation. Gusel ’VA, Smirnov DP. Farmakol Toksikol. 1980 Jul-Aug; 43 (4): 431-3

6. http://www.ncbi.nlm.nih.gov/pubmed/23391959

7. http://onlinelibrary.wiley.com/doi/10.1111/j.1527-3458.2001.tb00211.x/pdf

8. GABA Supplementation and Growth Hormone Response. Powers M. Lamprecht M (ed): Acute Topics in Sport Nutrition. Med Sport Sci. Basel, Karger, 2012, vol 59, pp 36–46

9. Powers, M. E., Yarrow, J. F., McCoy, S. C., & Borst, S. E. (2008). Growth hormone isoform responses to GABA ingestion at rest and after exercise. Medicine and science in sports and exercise, 40 (1), 104.

10. Cavagnini F, Benetti G, Invitti C, et al. Effect of gamma-aminobutyric acid on growth hormone and prolactin secretion in man: influence of pimozide and domperidone. J Clin Endocrinol Metab. 1980; 51: 789-92.

11. Cavagnini F, Invitti C, Pinto M, et al. Effect of acute and repeated administration of gamma aminobutyric acid (GABA) on growth hormone and prolactin secretion in man. Acta Endocrinol (Copenh). 1980; 93: 149-54.

12. http://www.ncbi.nlm.nih.gov/pubmed/16878492

13. http://www.ncbi.nlm.nih.gov/pubmed/20841974?dopt=Abstract

14. http://casereports.bmj.com/content/2013/bcr-2012-008381

15. http://www.ncbi.nlm.nih.gov/pubmed/2431377

16. http://www.ncbi.nlm.nih.gov/pubmed/19334513