What is a hydrophobic drug


AnointDosage forms Ointments are semi-solid preparations for external use that consist of a single-phase base in which solid or liquid substances can be dispersed. This is in contrast to the creams, which are multi-phase. Typical ointments are hydrophobic (greasy), are less absorbed than creams and have a low water content. However, this does not apply to all representatives. Ointments are used for skin care, as skin protection, and for the prevention and treatment of skin diseases. They are also used for the local or systemic administration of active substances.

synonym: Unguentum, Unguenta

Products

Ointments are commercially available as pharmaceuticals, medical devices and cosmetics. In colloquial language, ointments are used to describe various semi-solid preparations. In pharmacy, on the other hand, ointments are differentiated from creams, pastes and gels.

Structure and properties

Ointments are semi-solid preparations for external use. They consist of a single-phase base in which solid or liquid substances can be dispersed. This is in contrast to the creams, which are multi-phase and consist of a lipophilic and an aqueous phase.

The pharmacopoeia differentiates between hydrophobic ointments, water-absorbing ointments and hydrophilic ointments. Ointments can also contain emulsifiers and water.

For the production of ointments, for example fatty oils, fats, waxes, petroleum products such as petrolatum and paraffins, triglycerides and macrogols (PEG) can be used (see under ointment base).

In addition to the preparations for use on the skin, special ointments such as eye ointments and nasal ointments are also produced.

Effects

Ointments have skin-caring, skin-protecting, water-repellent (hydrophobic) and hydrating properties.

They are typically greasy, are less quickly absorbed than creams, and have a low water content. However, these characteristic properties do not apply to all preparations.

application areas

Ointments are mainly used for skin care, skin protection, prevention and treatment of skin diseases, wounds and injuries. They are also used for the local or systemic administration of active substances.

unwanted effects

The undesirable effects depend on the active ingredients used. Possible side effects of ointments include local reactions and allergic reactions.

see also

Ointment base

literature
  • Medicinal product information (CH, D)
  • European Pharmacopoeia PhEur
  • Pharmaceutical Technology Textbooks
author

Conflicts of Interest: None / Independent. The author has no relationships with the manufacturers and is not involved in the sale of the products mentioned.

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This article was last changed on 8/21/2020.
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